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SP110 antibody (N-Term)

SP110 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990831
  • Target See all SP110 Antibodies
    SP110 (SP110 Nuclear Body Protein (SP110))
    Binding Specificity
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 70-120, N-Term
    Reactivity
    • 21
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 15
    • 6
    Rabbit
    Clonality
    • 18
    • 3
    Polyclonal
    Conjugate
    • 18
    • 1
    • 1
    • 1
    This SP110 antibody is un-conjugated
    Application
    • 18
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    IPR1 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    IPR1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of the human IPR1. The immunogen is located within amino acids 70 - 120 of IPR1.
    Isotype
    IgG
    Top Product
    Discover our top product SP110 Primary Antibody
  • Application Notes
    Ipr1 antibody can be used for detection of Ipr1 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    IPR1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    IPR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SP110 (SP110 Nuclear Body Protein (SP110))
    Alternative Name
    IPR1 (SP110 Products)
    Synonyms
    SP110 antibody, IFI41 antibody, IFI75 antibody, IPR1 antibody, VODI antibody, 5031415C07Rik antibody, 52kDa antibody, 5830484A20Rik antibody, ENSMUSG00000075603 antibody, Ifi75 antibody, Ipr1 antibody, SP110 nuclear body protein antibody, Sp110 nuclear body protein antibody, SP110 antibody, Sp110 antibody
    Background
    IPR1 Antibody: Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.
    Gene ID
    3431
    NCBI Accession
    NP_004501
    UniProt
    Q9HB58
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