ATP11A antibody (N-Term)

Catalog No. ABIN783659

The Rabbit Polyclonal anti-ATP11A antibody has been validated for WB, IF and EIA. It is suitable to detect ATP11A in samples from Human, Mouse and Rat.

Quick Overview for ATP11A antibody (N-Term) (ABIN783659)

Target: ATP11A (ATPase, Class VI, Type 11A (ATP11A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP11A antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-ATP11A Antibody

Binding Specificity: N-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of human ATP11A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for ATP11A

Target: ATP11A (ATPase, Class VI, Type 11A (ATP11A))

Alternative Name: ATP11A

Background: ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.Synonyms: ATPIH, ATPIS, ATPase IS, ATPase class VI type 11A, KIAA1021, Probable phospholipid-transporting ATPase IH

Gene ID: 23250

NCBI Accession: NP_056020

UniProt: P98196