TMEM59 antibody (N-Term)

Catalog No. ABIN783793

This Rabbit Polyclonal antibody specifically detects TMEM59 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for TMEM59 antibody (N-Term) (ABIN783793)

Target: TMEM59 (Transmembrane Protein 59 (TMEM59))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM59 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-TMEM59 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects TMEM59 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near amino terminus of human TMEM59

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for TMEM59

Target: TMEM59 (Transmembrane Protein 59 (TMEM59))

Alternative Name: TMEM59

Background: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.Synonyms: C1orf8, HSPC001, Liver membrane-bound protein, Transmembrane protein 59

Gene ID: 9528

NCBI Accession: NP_004863

UniProt: Q9BXS4