BCL2L14 antibody (C-Term)

Catalog No. ABIN783818

The Rabbit Polyclonal anti-BCL2L14 antibody is suitable to detect BCL2L14 in samples from Human, Mouse and Rat. It has been validated for WB, IHC (p) and EIA.

Quick Overview for BCL2L14 antibody (C-Term) (ABIN783818)

Target: BCL2L14 (BCL2-Like 14 (Apoptosis Facilitator) (BCL2L14))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2L14 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-BCL2L14 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects Bcl-2-like 14 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Ion exchange chromatography purified

Immunogen: 15 amino acids near the C-terminus of human Bcl-G

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for BCL2L14

Target: BCL2L14 (BCL2-Like 14 (Apoptosis Facilitator) (BCL2L14))

Alternative Name: Bcl-2-Like 14

Background: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain (reviewed in 1 and 2). BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bcl-G (3). The mRNA of Bcl-G encodes 2 isoforms, Bcl-GL, which is widely expressed in multiple tissues, and Bcl-GS, which is only found in testis. The Bcl-GS protein is predominantly localized to cytoplasmic organelles whereas Bcl-GL was distributed throughout the cytosol. Overexpression of either protein induced apoptosis, although Bcl-GS was far more potent than Bcl-GS. Apoptosis induction was dependent on the BH3 domain and could be suppressed by co-expression with the anti-apoptotic Bcl-XL protein (3).Synonyms: Apoptosis facilitator Bcl-2-like protein 14, BCL2L14, BCLG, Bcl-G, Bcl2-L-14

Gene ID: 79370

NCBI Accession: NP_110393

UniProt: Q9BZR8