RWDD3 antibody (N-Term)

Catalog No. ABIN783831

The Rabbit Polyclonal anti-RWDD3 antibody (ABIN783831) specifically detects RWDD3 in WB and EIA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RWDD3 antibody (N-Term) (ABIN783831)

Target: RWDD3 (RWD Domain Containing 3 (RWDD3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RWDD3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-RWDD3 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to RWD domain containing 3.

Purification: Affinity chromatography

Immunogen: 17 amino acid peptide from near the amino terminus of human RWDD3.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for RWDD3

Target: RWDD3 (RWD Domain Containing 3 (RWDD3))

Alternative Name: RWDD3

Background: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.Synonyms: RSUME, RWD domain-containing protein 3, RWD-containing sumoylation enhancer

Gene ID: 25950

NCBI Accession: NP_001121614

UniProt: Q9Y3V2