GABBR1 antibody (pSer923) (Cy3)

Catalog No. ABIN800886

The Cy3-conjugated Rabbit Polyclonal anti-GABBR1 antibody (ABIN800886) specifically detects GABBR1 in WB, IF (cc) and IF (p). The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for GABBR1 antibody (pSer923) (Cy3) (ABIN800886)

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABBR1 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-GABBR1 Antibody (Cy3)

Binding Specificity: pSer923

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from mouse GABBR1 around the phosphorylation site of Ser923

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GABBR1

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Alternative Name: Gabbr1

Background:

Synonyms: GABBR1 phospho S1180, GABBR1 phospho Ser1180, p-GABBR1 Ser1180, GABAb Receptor 1, dJ271M21.1.1, dJ271M21.1.2, FLJ92613, GAB B R1, GABA B R1, GABAB R1, GABAB subunit 1c, GABAB1e, GABABR 1, GABABR1, GABB R1, GABBR 1, GABBR1 3, GABBR1, Gamma aminobutyric acid GABA B receptor 1, Gamma aminobutyric acid B receptor 1, Gamma aminobutyric acid type B receptor subunit 1, Gb 1, Gb1, GPRC 3A, GPRC3A, hGB1a, GABR1_HUMAN, Gamma-aminobutyric acid type B receptor subunit 1, GABA B Receptor 1, GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, Gb1, Seven transmembrane helix receptor.

Background: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009].

Gene ID: 54393

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process