LRP6 antibody (pThr1479)

Catalog No. ABIN801633

This anti-LRP6 antibody is a Rabbit Polyclonal antibody detecting LRP6 in WB, ELISA, IF (p), IF (cc), FACS, IHC (p) and IHC (fro). Suitable for Human and Mouse.

Quick Overview for LRP6 antibody (pThr1479) (ABIN801633)

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-LRP6 Antibody

Binding Specificity: pThr1479

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Dog,Cow,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Thr1479

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for LRP6

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Alternative Name: LRP6

Background:

Synonyms: LRP6 Thr1479, LRP6 T1479, p-LRP6 Thr1479, p-LRP6 T1479, ADCAD2, C030016K15Rik, Cd, FLJ90062, FLJ90421, Low density lipoprotein receptor related protein 6, LRP6_HUMAN, Low-density lipoprotein receptor-related protein 6, low-density lipoprotein receptor-related protein 6 precursor, LRP-6.

Background: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009].

Gene ID: 4040

UniProt: O75581

Pathways: WNT Signaling, Tube Formation