B-Cell Linker antibody

Catalog No. ABIN865398

This anti-B-Cell Linker antibody is a Mouse Monoclonal antibody detecting B-Cell Linker in WB, ELISA, IHC, FACS and IF. Suitable for Human and Mouse.

Quick Overview for B-Cell Linker antibody (ABIN865398)

Target: B-Cell Linker (BLNK)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This B-Cell Linker antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 5G9

Product Details anti-B-Cell Linker Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human BLNK expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: WB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100g/100l

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for B-Cell Linker

Target: B-Cell Linker (BLNK)

Alternative Name: BLNK

Background: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Synonyms: AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65, MGC111051

Molecular Weight: 68kDa

Gene ID: 29760

Pathways: BCR Signaling