TRERF1 antibody (AA 101-200)

Catalog No. ABIN872395

This Rabbit Polyclonal antibody specifically detects TRERF1 in ELISA, IF (cc), IF (p), IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for TRERF1 antibody (AA 101-200) (ABIN872395)

Target: TRERF1 (Transcriptional Regulating Factor 1 (TRERF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRERF1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TRERF1 Antibody

Binding Specificity: AA 101-200

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TReP132/RAPA

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TRERF1

Target: TRERF1 (Transcriptional Regulating Factor 1 (TRERF1))

Alternative Name: TReP132

Background:

Synonyms: BCAR2, Breast cancer anti estrogen resistance 2, Breast cancer anti-estrogen resistance 2, RAPA, rapa 1, rapa 2, rapa1, rapa2, RP1 139D8.5, Transcriptional regulating factor 1, Transcriptional regulating protein 132, Transcriptional-regulating factor 1, Transcriptional-regulating protein 132, TREF1_HUMAN, TReP 132, TREP132, TRERF1, Zinc finger protein rapa, Zinc finger transcription factor TReP 132, Zinc finger transcription factor TReP-132.

Background: Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.Tissue specificity:Highest expression was seen in thymus, testis and adrenal cortex, expressed also in the adrenal medulla, thyroid, and stomach. Highly expressed in steroidogenic JEG-3 and MCF-7 cells, low expression was seen in non-steroidogenic HepG2 and HK293 cells.

Gene ID: 55809

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding