NSD1 antibody (AA 2401-2600)

Catalog No. ABIN872593

This Rabbit Polyclonal antibody specifically detects NSD1 in ELISA, IF (cc), IF (p), IHC (fro) and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NSD1 antibody (AA 2401-2600) (ABIN872593)

Target: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NSD1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-NSD1 Antibody

Binding Specificity: AA 2401-2600

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NSD1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NSD1

Target: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Alternative Name: Nsd1

Background:

Synonyms: Androgen receptor coactivator 267 kDa protein, Androgen receptor-associated protein of 267 kDa, ARA267, H3 K36 HMTase, H3-K36-HMTase, H4 K20 HMTase, H4-K20-HMTase, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specic, KMT3B, Lysine N-methyltransferase 3B, NR binding SET domain containing protein, NR-binding SET domain-containing protein, Nsd1, NSD1_HUMAN, Nuclear receptor binding SET domain containing protein 1, Nuclear receptor-binding SET domain-containing protein 1.

Background: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

Gene ID: 64324