AEN antibody (AA 1-100)

Catalog No. ABIN872714

The Rabbit Polyclonal anti-AEN antibody is suitable to detect AEN in samples from Human. It has been validated for ELISA, WB, IHC (p), IF (cc), IF (p) and IHC (fro).

Quick Overview for AEN antibody (AA 1-100) (ABIN872714)

Target: AEN (Apoptosis Enhancing Nuclease (AEN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AEN antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-AEN Antibody

Binding Specificity: AA 1-100

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Apoptosis enhancing nuclease

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for AEN

Target: AEN (Apoptosis Enhancing Nuclease (AEN))

Alternative Name: Apoptosis enhancing nuclease

Background:

Synonyms: Aen, AEN_HUMAN, apoptosis enhancing nuclease, Apoptosis-enhancing nuclease, Interferon stimulated exonuclease gene 20 kDa like 1, Interferon stimulated exonuclease gene 20 kDa like 1, isoform CRA_a, Interferon-stimulated 20 kDa exonuclease-like 1, ISG20L1, pp12744.

Background: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.