APOB antibody (AA 1501-1700)

Catalog No. ABIN872950

This Rabbit Polyclonal antibody specifically detects APOB in WB. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for APOB antibody (AA 1501-1700) (ABIN872950)

Target: APOB (Apolipoprotein B (APOB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APOB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-APOB Antibody

Binding Specificity: AA 1501-1700

Predicted Reactivity: Human,Mouse,Rat,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Apolipoprotein B

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-APOB antibody (ABIN872950)

Choi, de Poot, Lee, Kim, Han, Kim, Finley, Lee: "Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation." in: Nature communications, Vol. 7, pp. 10963, (2016) (PubMed).

Target Details for APOB

Target: APOB (Apolipoprotein B (APOB))

Alternative Name: Apolipoprotein B

Background:

Synonyms: Apo B 100, Apo B, Apo B-100, Apo B-48, ApoB 100, ApoB 48, ApoB, APOB protein, APOB_HUMAN, Apolipoprotein B 100, Apolipoprotein B 48, Apolipoprotein B, Apolipoprotein B-48, FLDB.

Background: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia.Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.

Gene ID: 338

Pathways: Lipid Metabolism