HDAC6 antibody (pSer22) (AbBy Fluor® 555)

Catalog No. ABIN874903

This Rabbit Polyclonal antibody specifically detects HDAC6 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for HDAC6 antibody (pSer22) (AbBy Fluor® 555) (ABIN874903)

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC6 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HDAC6 Antibody (AbBy Fluor® 555)

Binding Specificity: pSer22

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human HDAC6 around the phosphorylation site of Ser22

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HDAC6

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Alternative Name: HDAC6

Background:

Synonyms: HDAC6 phospho S22, HDAC6 phospho Ser22, p-HDAC6 Ser22, HD 6, HD6, HDAC 6, Histone deacetylase 6, HD6, Histone deacetylase 6, JM 21, JM21, KIAA0901, FLJ16239, HDAC6_HUMAN.

Background: HDAC6 is a member of the class II mammalian histone deacetylases. Human HDAC6 is composed of 1215 amino acid residues. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.

Gene ID: 10013

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling