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IRS1 antibody (Insulin Receptor Substrate 1) (pSer307) (Alexa Fluor 555) Primary Antibody

IRS1 Reactivity: Human, Mouse, Rat, Goat FACS, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 555
Catalog No. ABIN875449
$442.20
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
  • Target
    IRS1
    Binding Specificity
    • 31
    • 29
    • 25
    • 21
    • 20
    • 20
    • 19
    • 17
    • 17
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 13
    • 11
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer307
    Reactivity
    • 376
    • 307
    • 282
    • 34
    • 27
    • 19
    • 18
    • 18
    • 16
    • 15
    • 13
    • 10
    • 2
    Human, Mouse, Rat, Goat
    Host
    • 380
    • 14
    Rabbit
    Clonality
    • 372
    • 22
    Polyclonal
    Conjugate
    • 157
    • 23
    • 19
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 15
    • 14
    • 14
    • 14
    • 14
    • 14
    • 11
    • 2
    • 1
    • 1
    • 1
    This IRS1 antibody is conjugated to Alexa Fluor 555
    Application
    • 178
    • 145
    • 138
    • 106
    • 104
    • 93
    • 67
    • 53
    • 24
    • 24
    • 19
    • 11
    • 7
    • 2
    • 2
    Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Specificity
    This phosphorylation site is homologous to Ser302 in Mouse and Rat.
    Cross-Reactivity
    Cow, Dog, Horse, Pig, Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Ser307 [TE(p-S)IT]
    Isotype
    IgG
  • Application Notes
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 4 °C
    Expiry Date
    12 months
  • Target
    IRS1
    Alternative Name
    IRS-1 (IRS1 Antibody Abstract)
    Synonyms
    HIRS-1, G972R, IRS-1, IRS1IRM, irs1, irsu, IRS1, irs-1, irs1-a, insulin receptor substrate 1, insulin receptor substrate 2, insulin receptor substrate 1 S homeolog, IRS1, Irs1, irs2, irs1.S
    Background

    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

    Subcellular location: Cell membrane

    Synonyms: HIRS-1, Insulin receptor substrate 1, IRS-1, IRS1

    Gene ID
    3667
    UniProt
    P35568
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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