Angiopoietin 2 antibody (AA 401-496) (AbBy Fluor® 350)

Catalog No. ABIN882571

This Rabbit Polyclonal antibody specifically detects Angiopoietin 2 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for Angiopoietin 2 antibody (AA 401-496) (AbBy Fluor® 350) (ABIN882571)

Target: Angiopoietin 2 (ANGPT2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiopoietin 2 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Angiopoietin 2 Antibody (AbBy Fluor® 350)

Binding Specificity: AA 401-496

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Angiopoietin 2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Angiopoietin 2

Target: Angiopoietin 2 (ANGPT2)

Alternative Name: Angiopoietin 2

Background:

Synonyms: ANG2, AGPT2, Angiopoietin-2, ANG-2, ANGPT2

Background: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Gene ID: 285

UniProt: O15123

Pathways: RTK Signaling