Ataxin 2 antibody (AA 775-856) (AbBy Fluor® 647)

Catalog No. ABIN884129

The Rabbit Polyclonal anti-Ataxin 2 antibody has been validated for WB, IF (cc), IF (p). It is suitable to detect Ataxin 2 in samples from Mouse.

Quick Overview for Ataxin 2 antibody (AA 775-856) (AbBy Fluor® 647) (ABIN884129)

Target: Ataxin 2 (ATXN2)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ataxin 2 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Ataxin 2 Antibody (AbBy Fluor® 647)

Binding Specificity: AA 775-856

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ATX2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Ataxin 2

Target: Ataxin 2 (ATXN2)

Alternative Name: ATX2

Background:

Synonyms: ATX2, SCA2, ASL13, TNRC13, Ataxin-2, Spinocerebellar ataxia type 2 protein, Trinucleotide repeat-containing gene 13 protein, ATXN2

Background: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ATX2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. ATX2 is caused by expansion of a CAG repeat in the coding region of ATX2. Longer expansions result in earlier onset of the disease. There are four named isoforms.

Gene ID: 6311

UniProt: Q99700

Pathways: Ribonucleoprotein Complex Subunit Organization