Bax beta antibody (AA 141-218) (Biotin)

Catalog No. ABIN884818

This Rabbit Polyclonal antibody specifically detects Bax beta in ELISA, IHC (fro) and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Bax beta antibody (AA 141-218) (Biotin) (ABIN884818)

Target: Bax beta (BAX beta) (BCL2-Associated X Protein (Isoform beta) (BAX beta))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Bax beta antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Bax beta Antibody (Biotin)

Binding Specificity: AA 141-218

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Bax isoform beta

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Bax beta

Target: Bax beta (BAX beta) (BCL2-Associated X Protein (Isoform beta) (BAX beta))

Background:

Synonyms: Apoptosis regulator Bax cytoplasmic isoform beta, BAX, Bax B, Bax beta, BaxB, BCL2 associated X protein, BCL2 associated X protein isoform beta.

Background: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008].

Gene ID: 581

UniProt: Q07812