Cathepsin K antibody (AbBy Fluor® 555)

Catalog No. ABIN886799

The Rabbit Polyclonal anti-Cathepsin K antibody has been validated for WB. It is suitable to detect Cathepsin K in samples from Human, Rat and Mouse.

Quick Overview for Cathepsin K antibody (AbBy Fluor® 555) (ABIN886799)

Target: Cathepsin K (CTSK)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin K antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB)

Product Details anti-Cathepsin K Antibody (AbBy Fluor® 555)

Cross-Reactivity: Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Capsin K

Isotype: IgG

Application Details

Application Notes: IF(IHC-P): 1:50-200
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: Cathepsin K

Background:

Synonyms: Cathepsin K, Procathepsin K, Cathepsin K precursor, Cathepsin O, Cathepsin O1, Cathepsin O2, Cathepsin X, CathepsinK, CTS02, CTSK, CTSK protein, CTSO, CTSO1, CTSO2, MGC23107, PKND, PYCD, Pycnodysostosis, cath-K, CK.

Background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008].

Gene ID: 1513

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades