CCDC43 antibody (AA 151-224) (AbBy Fluor® 488)

Catalog No. ABIN887756

The Rabbit Polyclonal anti-CCDC43 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect CCDC43 in samples from Human.

Quick Overview for CCDC43 antibody (AA 151-224) (AbBy Fluor® 488) (ABIN887756)

Target: CCDC43 (Coiled-Coil Domain Containing 43 (CCDC43))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC43 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CCDC43 Antibody (AbBy Fluor® 488)

Binding Specificity: AA 151-224

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CCDC43

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CCDC43

Target: CCDC43 (Coiled-Coil Domain Containing 43 (CCDC43))

Alternative Name: CCDC43

Background:

Synonyms: CCDC 43, Coiled coil domain containing 43, coiled coil domain containing protein 43, FLJ31795, CCD43_HUMAN.

Background: The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC43 (coiled-coil domain containing 43) is a 224 amino acid protein encoded by a gene that maps to human chromosome 17q21.31. Encoding over 1,200 genes, chromosome 17 comprises over 2.5 % of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome.

Gene ID: 124808