CCT8L2 antibody (AA 509-557) (Biotin)

Catalog No. ABIN890249

The Rabbit Polyclonal anti-CCT8L2 antibody is suitable to detect CCT8L2 in samples from Human. It has been validated for WB, ELISA, IHC (p) and IHC (fro).

Quick Overview for CCT8L2 antibody (AA 509-557) (Biotin) (ABIN890249)

Target: CCT8L2 (Chaperonin Containing TCP1, Subunit 8 (Theta)-Like 2 (CCT8L2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCT8L2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CCT8L2 Antibody (Biotin)

Binding Specificity: AA 509-557

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CESK1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CCT8L2

Target: CCT8L2 (Chaperonin Containing TCP1, Subunit 8 (Theta)-Like 2 (CCT8L2))

Alternative Name: CESK1

Background:

Synonyms: CCT8L2, KCNMB3L, T complex protein 1, CESK1, chaperonin containing TCP1, subunit 8 theta-like 2, Putative T-complex protein 1 subunit theta-like 2, T complex protein 1, chaperonin containing TCP1, subunit 8 theta-like 2, TCPQM_HUMAN.

Background: CESK1, also known as CCT8L2 (chaperonin containing TCP1, subunit 8 theta-like 2), is a 557 amino acid protein that localizes to the cytoplasm and is thought to function as a molecular chaperone, possibly assisting protein folding after ATP hydrolysis. CESK1 belongs to the TCP-1 chaperonin family and is encoded by a gene which maps to human chromosome 22. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein Bcr-Abl, a potent cell proliferation activator found in several types of leukemias.

Gene ID: 150160