CLIC4 antibody (AA 181-253) (Biotin)

Catalog No. ABIN891278

The Rabbit Polyclonal anti-CLIC4 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect CLIC4 in samples from Human.

Quick Overview for CLIC4 antibody (AA 181-253) (Biotin) (ABIN891278)

Target: CLIC4 (Chloride Intracellular Channel 4 (CLIC4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLIC4 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CLIC4 Antibody (Biotin)

Binding Specificity: AA 181-253

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CLIC4

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CLIC4

Target: CLIC4 (Chloride Intracellular Channel 4 (CLIC4))

Alternative Name: CLIC4

Background:

Synonyms: MC3S5, Chloride intracellular channel 4, Chloride intracellular channel 4 mitochondrial, Chloride intracellular channel 4 like, Chloride intracellular channel protein 4, Clic4, CLIC4_HUMAN, CLIC4L, DKFZP566G223, FLJ38640, H1 antibody HUH1, Intracellular chloride ion channel protein p64H1, mtCLIC, p64H1.

Background: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH . Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis.Tissue specificity: Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.

Gene ID: 25932