FOXL2 antibody (AbBy Fluor® 555)

Catalog No. ABIN897559

This Rabbit Polyclonal antibody specifically detects FOXL2 in WB and IF (p). It exhibits reactivity toward Human, Mouse, Rat, Cow, Pig and Dog.

Quick Overview for FOXL2 antibody (AbBy Fluor® 555) (ABIN897559)

Target: FOXL2 (Forkhead Box L2 (FOXL2))

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXL2 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-FOXL2 Antibody (AbBy Fluor® 555)

Cross-Reactivity: Cow, Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FOXL2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FOXL2

Target: FOXL2 (Forkhead Box L2 (FOXL2))

Alternative Name: FOXL2

Background:

Synonyms: blepharophimosis, Blepharophimosis epicanthus inversus and ptosis 1, Blepharophimosis epicanthus inversus and ptosis, BPES 1, BPES, BPES1, epicanthus inversus and ptosis 1, forkhead box L2, Forkhead box protein L2, forkhead transcription factor FOXL2, FOX L2, FOXL 2, FOXL2, FOXL2_HUMAN, PFRK, PINTO, POF 3, POF3.

Background: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis throught transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

Molecular Weight: 45-50kDa

Gene ID: 668

Pathways: Nuclear Hormone Receptor Binding, Positive Regulation of Endopeptidase Activity