GCH1 antibody (AA 34-110) (AbBy Fluor® 488)

Catalog No. ABIN899918

The Rabbit Polyclonal anti-GCH1 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect GCH1 in samples from Mouse.

Quick Overview for GCH1 antibody (AA 34-110) (AbBy Fluor® 488) (ABIN899918)

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCH1 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-GCH1 Antibody (AbBy Fluor® 488)

Binding Specificity: AA 34-110

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GTP-CH-1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GCH1

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Alternative Name: GTP cyclohydrolase 1

Background:

Synonyms: GTP-CH-1, DYT 5, DYT5, GCH 1, GCH, GCH1, GTP CH 1, GTP CH I, GTP cyclohydrolase 1 dopa responsive dystonia, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTPCH 1, GTPCH1, Guanosine 5' triphosphate cyclohydrolase I.

Background: GTP cyclohydrolase I (also designated dopa-responsive dystonia) catalyzes the conversion of GTP to D-erythro-7,8-dihydroneopterin triphosphate, the first and rate-limiting step in tetrahydrobiopterin (BH4) biosynthesis. Tetrahydrobiopterin is an essential cofactor for 3 aromatic amino acid monooxygenases: phenylalanine, tyrosine, and tryptophan hydroxylases. Animals can synthesize tetrahydrobiopterin in vivo from GTP through several enzymatic reactions.

Gene ID: 2643