KLHL21 antibody (AA 51-110) (FITC)

Catalog No. ABIN903934

This Rabbit Polyclonal antibody specifically detects KLHL21 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for KLHL21 antibody (AA 51-110) (FITC) (ABIN903934)

Target: KLHL21 (Kelch-Like 21 (KLHL21))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLHL21 antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-KLHL21 Antibody (FITC)

Binding Specificity: AA 51-110

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KLHL21

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KLHL21

Target: KLHL21 (Kelch-Like 21 (KLHL21))

Alternative Name: KLHL21

Background:

Synonyms: Kelch like protein 21, KIAA0469, KLHL21, MGC99635, KLH21_HUMAN.

Background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

Gene ID: 9903

Pathways: M Phase