PLSCR3 antibody (AA 201-295) (Cy5.5)

Catalog No. ABIN911534

The Rabbit Polyclonal anti-PLSCR3 antibody has been validated for IF (cc) and IF (p). It is suitable to detect PLSCR3 in samples from Human.

Quick Overview for PLSCR3 antibody (AA 201-295) (Cy5.5) (ABIN911534)

Target: PLSCR3 (phospholipid Scramblase 3 (PLSCR3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLSCR3 antibody is conjugated to Cy5.5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-PLSCR3 Antibody (Cy5.5)

Binding Specificity: AA 201-295

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PLSCR3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PLSCR3

Target: PLSCR3 (phospholipid Scramblase 3 (PLSCR3))

Alternative Name: PLSCR3

Background:

Synonyms: Ca2+-dependent phospholipid scramblase 3, Phospholipid scramblase 3, PL scramblase 3, PLS3, PLS3_HUMAN.

Background: PLSCR3 (phospholipid scramblase 3) may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Members of this family, PLS1 and PLS3 are both substrates of Protein kinase C (PKC) delta and are phosphorylated by PKC-delta during apoptosis. PKC-delta translocates to mitochondria during apoptosis and phosphorylates PLS3. Overexpression of PLS3 in the HEK293 cells enhanced apoptosis induced by UV-irradiation.

Gene ID: 57048

Pathways: Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis