TMEM123 antibody (AA 101-180) (PE)

Catalog No. ABIN911732

The Rabbit Polyclonal anti-TMEM123 antibody has been validated for WB and FACS. It is suitable to detect TMEM123 in samples from Human, Mouse and Rat.

Quick Overview for TMEM123 antibody (AA 101-180) (PE) (ABIN911732)

Target: TMEM123 (Transmembrane Protein 123 (TMEM123))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM123 antibody is conjugated to PE

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-TMEM123 Antibody (PE)

Binding Specificity: AA 101-180

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Porimin

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TMEM123

Target: TMEM123 (Transmembrane Protein 123 (TMEM123))

Alternative Name: Porimin

Background:

Synonyms: KCT3, Keratinocytes associated transmembrane protein 3, Pro oncosis receptor inducing membrane injury, Serine/threonine rich receptor, TMEM123, Transmembrane protein 123, PORIM_HUMAN.

Background: This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti PORIMIN (pro oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.

Molecular Weight: 24kDa

Gene ID: 114908

Pathways: Regulation of Cell Size