SLC5A8 antibody (AA 301-336) (AbBy Fluor® 350)

Catalog No. ABIN915605

The Rabbit Polyclonal anti-SLC5A8 antibody is suitable to detect SLC5A8 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for SLC5A8 antibody (AA 301-336) (AbBy Fluor® 350) (ABIN915605)

Target: SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC5A8 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB)

Product Details anti-SLC5A8 Antibody (AbBy Fluor® 350)

Binding Specificity: AA 301-336

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SLC5A8

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SLC5A8

Target: SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))

Alternative Name: Slc5a8

Background:

Synonyms: AIT, SMCT, SMCT1, Sodium-coupled monocarboxylate transporter 1, Apical iodide transporter, Electrogenic sodium monocarboxylate cotransporter, Sodium iodide-related cotransporter, Solute carrier family 5 member 8, SLC5A8

Background: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

Gene ID: 160728

UniProt: Q8N695