UBE2V1 antibody (AA 51-147) (Cy7)

Catalog No. ABIN919166

The Rabbit Polyclonal anti-UBE2V1 antibody is suitable to detect UBE2V1 in samples from Human and Rat. It has been validated for WB, FACS, IF (cc) and IF (p).

Quick Overview for UBE2V1 antibody (AA 51-147) (Cy7) (ABIN919166)

Target: UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2V1 antibody is conjugated to Cy7

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-UBE2V1 Antibody (Cy7)

Binding Specificity: AA 51-147

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UBE2V1

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for UBE2V1

Target: UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))

Alternative Name: UBE2V1

Background:

Synonyms: CIR1, CROC-1, CROC1, CROC1A, TRAF6-regulated IKK activator 1 beta Uev1A, UB2V1_HUMAN, UBE2V 1, UBE2V, UBE2V1, Ubiquitin conjugating enzyme E2 variant 1, Ubiquitin-conjugating enzyme E2 variant 1, UEV-1, UEV1.

Background: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Gene ID: 7335

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades