PVRL2 antibody

Catalog No. ABIN920706

This anti-PVRL2 antibody is a Rat Monoclonal antibody detecting PVRL2 in WB, IHC, FACS and IP. Suitable for Human and Mouse.

Quick Overview for PVRL2 antibody (ABIN920706)

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Reactivity: Human, Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This PVRL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: 502-57

Product Details anti-PVRL2 Antibody

Specificity: Reacts with nectin-2.

Purification: Purified

Immunogen: The extracellular domain of mouse nectin-2.

Isotype: IgG2a

Application Details

Application Notes: Immunohistochemistry: (frozen sections) Use at a 1:10 dilution. Flow cytometry: Use at a 1:10 dilution. Western blot: Use at a 1:10 dilution. Fixation with PFA or acetone/methanol is recommended.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 1 mL of 100 µg/mL

Storage: 4 °C

Target Details for PVRL2

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Alternative Name: Nectin-2

Background: Nectin (originally isolated as poliovirus receptor- related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is co-localized with afadin at cadherin-based cell-cell adherence juctions in various tissues and cell lines. The nectin family consists of nectin-1, nectin-2 and nectin-3. Nectin-2 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cells lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice. Synonyms: PRR2, CD112

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization