DDB2 antibody (C-Term)

Catalog No. ABIN926426

The Rabbit Polyclonal anti-DDB2 antibody has been validated for WB. It is suitable to detect DDB2 in samples from Human.

Quick Overview for DDB2 antibody (C-Term) (ABIN926426)

Target: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DDB2 Antibody

Binding Specificity: C-Term

Purification: Purified

Immunogen: DDB2 antibody was raised in rabbit using the C terminal of DDB2 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

DDB2 Blocking Peptide, (ABIN939596), is also available for use as a blocking control in assays to test for specificity of this DDB2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for DDB2

Target: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Alternative Name: DDB2

Background: This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Synonyms: Polyclonal DDB2 antibody, Anti-DDB2 antibody, damage-specific DNA binding protein 2, 48kDa antibody, DDBB antibody, FLJ34321 antibody, UV-DDB2 antibody.

Pathways: DNA Damage Repair