KPNB1 antibody (N-Term)

Catalog No. ABIN926686

This Rabbit Polyclonal antibody specifically detects KPNB1 in WB. It exhibits reactivity toward Human.

Quick Overview for KPNB1 antibody (N-Term) (ABIN926686)

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KPNB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KPNB1 Antibody

Binding Specificity: N-Term

Purification: Purified

Immunogen: KPNB1 antibody was raised in rabbit using the N terminal of KPNB1 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

KPNB1 Blocking Peptide, (ABIN937840), is also available for use as a blocking control in assays to test for specificity of this KPNB1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for KPNB1

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Alternative Name: KPNB1

Background: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Synonyms: Polyclonal KPNB1 antibody, Anti-KPNB1 antibody, karyopherin, importin beta 1 antibody, IMB1 antibody, IPO1 antibody, IPOB antibody, Impnb antibody, MGC2155 antibody, MGC2156 antibody, MGC2157 antibody, NTF97 antibody.

Pathways: Protein targeting to Nucleus