CXCL12 antibody (Middle Region)

Catalog No. ABIN926925

This anti-CXCL12 antibody is a Rabbit Polyclonal antibody detecting CXCL12 in WB. Suitable for Human, Mouse, Rat, Dog, Pig, Cow, Chicken and Xenopus laevis.

Quick Overview for CXCL12 antibody (Middle Region) (ABIN926925)

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCL12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CXCL12 Antibody

Binding Specificity: Middle Region

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Frog, Pig (Porcine), Dog (Canine), Chicken, Cow (Bovine)

Purification: Purified

Immunogen: CXCL12 antibody was raised in rabbit using the middle region of CXCL12 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

CXCL12 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this CXCL12 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for CXCL12

Target: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Alternative Name: CXCL12

Background: Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. The intercrines are characterized by the presence of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group. Synonyms: Polyclonal CXCL12 antibody, Anti-CXCL12 antibody, chemokine, C-X-C motif ligand 12, stromal cell-derived factor 1 antibody.

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling