CHRNB3 antibody (Middle Region)

Catalog No. ABIN926966

The Rabbit Polyclonal anti-CHRNB3 antibody has been validated for WB. It is suitable to detect CHRNB3 in samples from Human, Mouse, Rat, Dog, Chicken and Xenopus laevis.

Quick Overview for CHRNB3 antibody (Middle Region) (ABIN926966)

Target: CHRNB3 (Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))

Reactivity: Human, Mouse, Rat, Dog, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNB3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CHRNB3 Antibody

Binding Specificity: Middle Region

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken, Frog

Purification: Purified

Immunogen: CHRNB3 antibody was raised in rabbit using the middle region of CHRNB3 as the immunogen

Application Details

Application Notes: WB: 0.03 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

CHRNB3 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this CHRNB3 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for CHRNB3

Target: CHRNB3 (Cholinergic Receptor, Nicotinic, beta 3 (Neuronal) (CHRNB3))

Alternative Name: CHRNB3

Background: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits. CHRNB3 is one of the subunits of nAChR. Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4. CHRNB3 decreased the channel mean open time and burst length. There was also an increase in single channel slope conductance. On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3. Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimer's and Parkinson's diseases. nAChRs also play a significant role in nicotine addiction. Synonyms: Polyclonal CHRNB3 antibody, Anti-CHRNB3 antibody, cholinergic receptor, nicotinic, beta 3 antibody.