RBM5 antibody (N-Term)

Catalog No. ABIN927731

The Rabbit Polyclonal anti-RBM5 antibody has been validated for WB. It is suitable to detect RBM5 in samples from Human, Mouse, Rat, Cow, Dog, Chicken and Xenopus laevis.

Quick Overview for RBM5 antibody (N-Term) (ABIN927731)

Target: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Reactivity: Human, Mouse, Rat, Cow, Dog, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RBM5 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Frog, Chicken

Purification: Purified

Immunogen: RBM5 antibody was raised in rabbit using the N terminal of RBM5 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

RBM5 Blocking Peptide, (ABIN938939), is also available for use as a blocking control in assays to test for specificity of this RBM5 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for RBM5

Target: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Alternative Name: RBM5

Background: RBM5 is a component of the spliceosome A complex.It regulates alternative splicing of a number of mRNAs. RBM5 may modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. RBM5 may both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, RBM5 promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. Synonyms: Polyclonal RBM5 antibody, Anti-RBM5 antibody, RNA binding motif protein 5 antibody, FLJ39876 antibody, G15 antibody, H37 antibody, LUCA15 antibody, RMB5 antibody.

Pathways: Ribonucleoprotein Complex Subunit Organization