Parkin antibody (C-Term)

Catalog No. ABIN928012

This Rabbit Polyclonal antibody specifically detects Parkin in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for Parkin antibody (C-Term) (ABIN928012)

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Parkin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Parkin Antibody

Binding Specificity: C-Term

Cross-Reactivity: Mouse (Murine)

Purification: Purified

Immunogen: Park2 antibody was raised in rabbit using the C terminal of Park2 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

Park2 Blocking Peptide, (ABIN936245), is also available for use as a blocking control in assays to test for specificity of this Park2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for Parkin

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Alternative Name: Park2

Background: Park2 functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. Park2 may play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Park2 limits the production of reactive oxygen species (ROS). Synonyms: Polyclonal Park2 antibody, Anti-Park2 antibody, Parkinson disease, autosomal recessive, juvenile 2, parkin antibody, MGC130518 antibody, PRKN antibody.

Pathways: Autophagy, Ubiquitin Proteasome Pathway