NUMA1 antibody (C-Term)

Catalog No. ABIN928379

The Rabbit Polyclonal anti-NUMA1 antibody is suitable to detect NUMA1 in samples from Human, Mouse, Rat, Chicken and Xenopus laevis. It has been validated for WB.

Quick Overview for NUMA1 antibody (C-Term) (ABIN928379)

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Reactivity: Human, Mouse, Rat, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NUMA1 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Rat (Rattus), Mouse (Murine), Chicken, Frog

Purification: Purified

Immunogen: NUMA1 antibody was raised in rabbit using the C terminal of NUMA1 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

NUMA1 Blocking Peptide, (ABIN936841), is also available for use as a blocking control in assays to test for specificity of this NUMA1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for NUMA1

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Alternative Name: NUMA1

Background: NuMA is a structural element in maintaining nuclear integrity. A critical spindle pole-associated mechanism, called the END (Emi1/NuMA/dynein-dynactin) network, spatially restricts APC/C activity in early mitosis. The entire coding region and exon-intron boundaries of NuMa were screened in 92 familial breast cancer patients. But the results do not support the role of NuMA variants as breast cancer susceptibility alleles. Synonyms: Polyclonal NUMA1 antibody, Anti-NUMA1 antibody, nuclear mitotic apparatus protein 1 antibody, NUMA antibody.

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, M Phase