FE65 antibody (N-Term)

Catalog No. ABIN928785

The Rabbit Polyclonal anti-FE65 antibody (ABIN928785) specifically detects FE65 in WB. The antibody is reactive with Mouse and Human samples.

Quick Overview for FE65 antibody (N-Term) (ABIN928785)

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Reactivity: Mouse, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FE65 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FE65 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Mouse (Murine)

Purification: Purified

Immunogen: Apbb1 antibody was raised in rabbit using the N terminal of Apbb1 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

Apbb1 Blocking Peptide, (ABIN937349), is also available for use as a blocking control in assays to test for specificity of this Apbb1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for FE65

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Alternative Name: Apbb1

Background: Apbb1 is an adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain.Apbb1 plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. Apbb1 may act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Synonyms: Polyclonal Apbb1 antibody, Anti-Apbb1 antibody, amyloid beta, A4 precursor protein-binding, family B, member 1 antibody, Fe65 antibody, Rir antibody.

Pathways: Positive Regulation of Response to DNA Damage Stimulus