PDE8A antibody (C-Term)

Catalog No. ABIN928993

This Rabbit Polyclonal antibody specifically detects PDE8A in WB. It exhibits reactivity toward Human.

Quick Overview for PDE8A antibody (C-Term) (ABIN928993)

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE8A Antibody

Binding Specificity: C-Term

Purification: Purified

Immunogen: PDE8 A antibody was raised in rabbit using the C terminal of PDE8 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

PDE8A Blocking Peptide, (ABIN5615278), is also available for use as a blocking control in assays to test for specificity of this PDE8A antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for PDE8A

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Alternative Name: PDE8A

Background: Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling. Synonyms: Polyclonal PDE8A antibody, Anti-PDE8A antibody, phosphodiesterase 8A antibody, FLJ16150 antibody, HsT19550 antibody.

Pathways: cAMP Metabolic Process