PDE8A antibody (C-Term)

Catalog No. ABIN2787372

The Rabbit Polyclonal anti-PDE8A antibody is suitable to detect PDE8A in samples from Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Pig, Guinea Pig and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for PDE8A antibody (C-Term) (ABIN2787372)

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Pig, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE8A Antibody

Binding Specificity: C-Term

Purpose: PDE8A Antibody - C-terminal region

Sequence: VSNPCRPLQY CIEWAARISE EYFSQTDEEK QQGLPVVMPV FDRNTCSIPK

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against PDE8A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PDE8A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57753-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDE8A

Target: PDE8A (phosphodiesterase 8A (PDE8A))

Alternative Name: PDE8A

Background:

Background Information: Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., MIM 2000). See MIM 171885.

Gene Name: Phosphodiesterase 8A

Alternative Symbols: HsT19550

Protein Name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Molecular Weight: 88kDa

Gene ID: 5151

NCBI Accession: NP_775656

UniProt: O60658

Pathways: cAMP Metabolic Process