Fibrillarin antibody

Catalog No. ABIN931035

This anti-Fibrillarin antibody is a Mouse Monoclonal antibody detecting Fibrillarin in DB. Suitable for Human.

Quick Overview for Fibrillarin antibody (ABIN931035)

Target: Fibrillarin (FBL)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fibrillarin antibody is un-conjugated

Application: Dot Blot (DB)

Clone: 2350C1

Product Details anti-Fibrillarin Antibody

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: FBL antibody was raised in mouse using recombinant Human Fibrillarin

Isotype: IgG1

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: FBL antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for Fibrillarin

Target: Fibrillarin (FBL)

Alternative Name: FBL

Background: This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. Synonyms: Monoclonal FBL antibody, Anti-FBL antibody, Fibrillarin antibody, FIB antibody, FLRN antibody, RNU3IP1 antibody.

Pathways: Ribonucleoside Biosynthetic Process