Fibrillarin antibody
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- Target See all Fibrillarin (FBL) Antibodies
- Fibrillarin (FBL)
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Fibrillarin antibody is un-conjugated
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Application
- Dot Blot (DB)
- Cross-Reactivity
- Human
- Cross-Reactivity (Details)
- Other species not studied.
- Purification
- Protein G affinity chromatography
- Immunogen
- FBL antibody was raised in mouse using recombinant Human Fibrillarin
- Clone
- 2350C1
- Isotype
- IgG1
- Top Product
- Discover our top product FBL Primary Antibody
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- Application Notes
- Optimal conditions should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- Lot specific
- Buffer
- FBL antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. - Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.
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- Target
- Fibrillarin (FBL)
- Alternative Name
- FBL (FBL Products)
- Background
- This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. Synonyms: Monoclonal FBL antibody, Anti-FBL antibody, Fibrillarin antibody, FIB antibody, FLRN antibody, RNU3IP1 antibody.
- Pathways
- Ribonucleoside Biosynthetic Process
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