ORC6 antibody

Catalog No. ABIN931160

The Mouse Monoclonal anti-ORC6 antibody has been validated for DB and ICC. It is suitable to detect ORC6 in samples from Human.

Quick Overview for ORC6 antibody (ABIN931160)

Target: ORC6 (Origin Recognition Complex, Subunit 6 (ORC6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ORC6 antibody is un-conjugated

Application: Dot Blot (DB), Immunocytochemistry (ICC)

Clone: 2679C2b

Product Details anti-ORC6 Antibody

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: ORC6 L antibody was raised in mouse using recombinant Human Origin Recognition Complex, Subunit 6 Like (Yeast) (Orc6 )

Isotype: IgG1

Application Details

Application Notes: ICC: 2-100 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: ORC6 L antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for ORC6

Target: ORC6 (Origin Recognition Complex, Subunit 6 (ORC6))

Alternative Name: ORC6L

Background: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. Synonyms: Monoclonal ORC6L antibody, Anti-ORC6L antibody, Origin recognition complex subunit 6 antibody, ORC6 antibody.

Pathways: Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA