RUVBL1 antibody

Catalog No. ABIN932457

This anti-RUVBL1 antibody is a Mouse Monoclonal antibody detecting RUVBL1 in WB, FACS, ICC and DB. Suitable for Human.

Quick Overview for RUVBL1 antibody (ABIN932457)

Target: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RUVBL1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Dot Blot (DB)

Clone: 2943C1a

Product Details anti-RUVBL1 Antibody

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: RUVBL1 antibody was raised in mouse using recombinant Human Ruvb-Like 1 (E. Coli) (Ruvbl1)

Isotype: IgG2b

Application Details

Application Notes: WB: 0.2-2 µg/mL, FC: 0.5-2 µg/sample, ICC: 2-100 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: RUVBL1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for RUVBL1

Target: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Alternative Name: RUVBL1

Background: This gene possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. Synonyms: Monoclonal RUVBL1 antibody, Anti-RUVBL1 antibody, RuvB (E coli homolog)-like 1 antibody, RVB1 antibody, ECP54 antibody, TIP49 antibody, NMP238 antibody, TIP49A antibody.

Pathways: Telomere Maintenance