SUPT4H antibody

Catalog No. ABIN932460

The Mouse Monoclonal anti-SUPT4H antibody (Clone 3079C1a) (ABIN932460) specifically detects SUPT4H in DB. The antibody is reactive with Human samples.

Quick Overview for SUPT4H antibody (ABIN932460)

Target: SUPT4H (SUPT4H1) (Suppressor of Ty 4 Homolog 1 (SUPT4H1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SUPT4H antibody is un-conjugated

Application: Dot Blot (DB)

Clone: 3079C1a

Product Details anti-SUPT4H Antibody

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: SUPT4 H1 antibody was raised in mouse using recombinant Human Suppressor Of Ty 4 Homolog 1 (S. Cerevisiae) (Supt4 1)

Isotype: IgG2b

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: SUPT4 H1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for SUPT4H

Target: SUPT4H (SUPT4H1) (Suppressor of Ty 4 Homolog 1 (SUPT4H1))

Alternative Name: SUPT4H1

Background: SUPT4H1 is a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. Synonyms: Monoclonal SUPT4H1 antibody, Anti-SUPT4H1 antibody, Suppressor of Ty 4 homolog 1 antibody, SPT4H antibody, SUPT4H antibody.