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HLA-DR1 antibody

HLA-DR1 Reactivity: Human FACS, ELISA, WB Host: Mouse Monoclonal MEM-267 unconjugated
Catalog No. ABIN94350
  • Target See all HLA-DR1 products
    HLA-DR1 (MHC Class II HLA-DR1 (HLA-DR1))
    Reactivity
    Human
    Host
    • 2
    Mouse
    Clonality
    • 2
    Monoclonal
    Conjugate
    • 2
    This HLA-DR1 antibody is un-conjugated
    Application
    Flow Cytometry (FACS), ELISA, Western Blotting (WB)
    Specificity
    The antibody MEM-267 specifically binds extracellularly to the empty but not peptide-loaded form of HLA-DR1. DR is the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC, dendritic cells, B lymphocytes, monocytes, macrophages).
    Cross-Reactivity (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
    Clone
    MEM-267
    Isotype
    IgG2b
  • Application Notes
    Flow cytometry: The antibody MEM-267 stains immature dendritic cells that express empty cell surface MHC molecules, but not cells that express predominantly peptide loaded forms.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Target
    HLA-DR1 (MHC Class II HLA-DR1 (HLA-DR1))
    Alternative Name
    HLA-DR1 (HLA-DR1 Products)
    Background
    HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.
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