CYP1A1 antibody (AA 1-512)

Catalog No. ABIN947763

Product Details anti-CYP1A1 Antibody

Target: CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))

Binding Specificity: AA 1-512

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This CYP1A1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Mouse polyclonal antibody raised against a full-length human CYP1A1 protein.

Sequence: MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH ACCEHFQMQL RS

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: CYP1A1 (NP_000490.1, 1 a.a. ~ 512 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CYP1A1 antibody (ABIN947763)

Zapletal, Tylichová, Neča, Kohoutek, Machala, Milcová, Pokorná, Topinka, Moyer, Hofmanová, Kozubík, Vondráček: "Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models." in: Archives of toxicology, Vol. 91, Issue 5, pp. 2135-2150, (2016) (PubMed).

Kabátková, Zapletal, Tylichová, Ne?a, Machala, Milcová, Topinka, Kozubík, Vondrá?ek: "Inhibition of ?-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation." in: Mutagenesis, Vol. 30, Issue 4, pp. 565-76, (2015) (PubMed).

Target Details for CYP1A1

Target: CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))

Alternative Name: CYP1A1 (CYP1A1 Products)

Background: Full Gene Name: cytochrome P450, family 1, subfamily A, polypeptide 1
Synonyms: AHH,AHRR,CP11,CYP1,P1-450,P450-C,P450DX

Gene ID: 1543

NCBI Accession: NM_000499

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha