CYP1A1 antibody (AA 200-460)

Catalog No. ABIN3023076

This Rabbit Polyclonal antibody specifically detects CYP1A1 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for CYP1A1 antibody (AA 200-460) (ABIN3023076)

Target: CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP1A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CYP1A1 Antibody

Binding Specificity: AA 200-460

Sequence: AICFGRRYDH NHQELLSLVN LNNNFGEVVG SGNPADFIPI LRYLPNPSLN AFKDLNEKFY SFMQKMVKEH YKTFEKGHIR DITDSLIEHC QEKQLDENAN VQLSDEKIIN IVLDLFGAGF DTVTTAISWS LMYLVMNPRV QRKIQEELDT VIGRSRRPRL SDRSHLPYME AFILETFRHS SFVPFTIPHS TTRDTSLKGF YIPKGRCVFV NQWQINHDQK LWVNPSEFLP ERFLTPDGAI DKVLSEKVII FGMGKRKCIG E

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human CYP1A1 (NP_000490.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CYP1A1

Target: CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 (CYP1A1))

Alternative Name: CYP1A1

Background: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown, however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,CYP1A1,AHH,AHRR,CP11,CYP1,CYPIA1,P1-450,P450-C,P450DX,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Cytochromes,Lipid Metabolism,Cytochromes,Lipases,Drug metabolism,Cardiovascular,Hypoxia,Lipids,CYP1A1

Molecular Weight: 18 kDa/20 kDa/58 kDa

Gene ID: 1543

UniProt: P04798

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha