BAG4 antibody (C-Term)

Catalog No. ABIN950598

This anti-BAG4 antibody is a Rabbit Polyclonal antibody detecting BAG4 in WB and EIA. Suitable for Human.

Quick Overview for BAG4 antibody (C-Term) (ABIN950598)

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAG4 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-BAG4 Antibody

Binding Specificity: AA 380-409, C-Term

Specificity: This antibody reacts to BAG4.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 380-409 amino acids from the C-terminal region of human BAG4

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for BAG4

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Alternative Name: BAG4

Background: BAG4 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.Synonyms: BAG family molecular chaperone regulator 4, BAG-4, Bcl-2-associated athanogene 4, SODD, Silencer of death domains

Gene ID: 9530

NCBI Accession: NP_004865

Pathways: Regulation of Actin Filament Polymerization