Cholesterol Esterase antibody (Middle Region)

Catalog No. ABIN950601

Product Details anti-Cholesterol Esterase Antibody

Target: Cholesterol Esterase (CEL)

Binding Specificity: AA 453-482, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cholesterol Esterase antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human CEL. Other species not tested.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 453-482 amino acids from the Central region of human CEL

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Cholesterol Esterase

Target: Cholesterol Esterase (CEL)

Alternative Name: BAL / CEL (CEL Products)

Background: The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein.Synonyms: BSDL, BSSL, Bile salt-activated lipase, Bile salt-stimulated lipase, Bucelipase, CELL, CEase, Carboxyl ester lipase, Cholesterol esterase, FAP, FAPP, LIPA, MODY8, Pancreatic lysophospholipase, Sterol esterase

Molecular Weight: 79322 Da

Gene ID: 1056

NCBI Accession: NP_001798

Pathways: Lipid Metabolism