CRYBA1 antibody (Middle Region)

Catalog No. ABIN950651

The Rabbit Polyclonal anti-CRYBA1 antibody has been validated for WB, IHC (p) and EIA. It is suitable to detect CRYBA1 in samples from Human and Mouse.

Quick Overview for CRYBA1 antibody (Middle Region) (ABIN950651)

Target: CRYBA1 (Crystallin, beta A1 (CRYBA1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRYBA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-CRYBA1 Antibody

Binding Specificity: AA 111-141, Middle Region

Specificity: This antibody recognizes Human and Mouse Beta-crystallin A3.

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 111-141 amino acids from the Central region of Human CRYBA1. Genename: CRYBA1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CRYBA1

Target: CRYBA1 (Crystallin, beta A1 (CRYBA1))

Alternative Name: beta-Crystallin A3

Background: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'Synonyms: CRYB1, CRYBA1

Molecular Weight: 25150 Da

Gene ID: 1411

NCBI Accession: NP_005199