IGSF8 antibody (Middle Region)

Catalog No. ABIN951296

The Rabbit Polyclonal anti-IGSF8 antibody is suitable to detect IGSF8 in samples from Human and Mouse. It has been validated for WB, IHC (p) and EIA.

Quick Overview for IGSF8 antibody (Middle Region) (ABIN951296)

Target: IGSF8 (Immunoglobulin Superfamily, Member 8 (IGSF8))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGSF8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-IGSF8 Antibody

Binding Specificity: AA 233-262, Middle Region

Specificity: This antibody detects IGSF8 (Center).

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse

Purification: Purified through a protein A column; followed by peptide affinity purification.

Immunogen: Synthetic peptide (233-262 aa) - KLH conjugated - corresponding to internal domain of human IGSF8.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IGSF8

Target: IGSF8 (Immunoglobulin Superfamily, Member 8 (IGSF8))

Alternative Name: CD316 / IGSF8

Background: GSF8/PGRL/EWI-2 is a membrane protein that contains 4 Ig domains and forms highly proximal, specific and stoichiometric complexes with both CD9 and CD81 a tetraspanin. Tetraspanins and their molecular partners from primary complexes that then undergo tetraspanin-tetraspanin interactions to form a network of molecular interactions call a tetraspanin web. IGSF8 then may play a key role in diverse functions ascribed to CD81 and CD9 including oocyte fertilization or hepatitis C virus function, regulation of proliferation and differentiation of keratinocytes. It may also be a negative regulator of cell motility and suppress T-cell mobility coordinately with CD81.Synonyms: CD81 partner 3, CD81P3, EWI2, Glu-Trp-Ile EWI motif-containing protein 2, Immunoglobulin superfamily member 8, KCT4, Keratinocytes-associated transmembrane protein 4, LIR-D1

Gene ID: 93185

NCBI Accession: NP_001193594